Bio-active Scaffold

          Natural Bone                                       Bio2 Bio-active Scaffold

Bio2’s initial bone scaffolding development has been focused on bio-active glass based materials. Bio-active glass is defined by a certain composition of inorganic materials. Once in the body, these materials initiate a biological response to re-model bone and eventually are absorbed into the body. These FDA clinically approved fibers have been used extensively in vivo in non-load bearing applications with demonstrated controlled dissolution rates. Applying CLM to bio-active glass fibers, Bio2 has created a tissue scaffolding which is both high strength and high porosity for load bearing applications. We are developing our  bio-active scaffold to implant as load bearing while transitioning to load sharing. By using bio-active glass fibers, bio-active CLM facilitates the transition of the medical industry from replacement to regenerative orthopedics.

Hydroxyapatite Formation during In Vitro Testing of Bio-active Scaffold

In vitro studies of our bio-active scaffold have formed hydroxyapatite on the surface of our scaffold, as seen in the image above. Hydroxyapatite is the primary mineral content of bone and calcified cartilage.  Bio2 is performing in vivo studies to broaden our understand the biological response of the bio-active scaffold.

Potential applications for Bio2 scaffolds may include knee osteotomy, spinal instrumentation, and bone trauma (fracture).